Neural Adaptation Leads to Cognitive Ethanol Dependence

Neural Adaptation Leads to Cognitive Ethanol Dependence

Physiological alcohol dependence is a key adaptation to chronic ethanol consumption that underlies withdrawal symptoms, is thought to directly contribute to alcohol addiction behaviors, and is associated with cognitive problems such as deficits in learning and memory. Based on the idea that an ethanol-adapted (dependent) animal will perform better in a learning assay than an animal experiencing...

Alcohol Addiction: Chronic Ethanol Leads to Cognitive Dependence in Drosophila

Recent studies have found that Drosophila show detrimental effects of withdrawal from ethanol on learning, a preference for stimuli associated with intoxication, and a tendency to consume ethanol after frustrating social situations.

How Adaptation of the Brain to Alcohol Leads to Dependence

The development of alcohol dependence is posited to involve numerous changes in brain chemistry (i.e., neurotransmission) that lead to physiological signs of withdrawal upon abstinence from alcohol as well as promote vulnerability to relapse in dependent people. These neuroadaptive changes often occur in those brain neurotransmission systems that are most sensitive to the acute, initial effects...

Adaptation to Chronic Nutritional Stress Leads to Reduced Dependence on Microbiota in Drosophila melanogaster

Numerous studies have shown that animal nutrition is tightly linked to gut microbiota, especially under nutritional stress. In Drosophila melanogaster, microbiota are known to promote juvenile growth, development, and survival on poor diets, mainly through enhanced digestion leading to changes in hormonal signaling. Here, we show that this reliance on microbiota is greatly reduced in replicated...

Disruption of GAL1 Gene in Saccharomyces cerevisiae Leads to Higher Ethanol Production